AustralieFrV1, Main, Exploration, bibRecord, 005D95

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms

Identifieur interne : 005D95 ( Main/Exploration ); précédent : 005D94; suivant : 005D96

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms

Auteurs : Hervé Ghesquieres [France] ; Guillaume Cartron [France] ; John Francis Seymour [Australie] ; Marie-Hélène Delfau-Larue [France] ; Fritz Offner [Belgique] ; Pierre Soubeyran [France] ; Aurore Perrot [France] ; Pauline Brice [France] ; Réda Bouabdallah [France] ; Anne Sonet [Belgique] ; Jehan Dupuis [France] ; Olivier Casasnovas [France] ; John Vincent Catalano [Australie] ; Alain Delmer [France] ; Fabrice Jardin [France] ; Aurélie Verney [France] ; Peggy Dartigues [France] ; Gilles Salles [France]

Source :

Blood [ 0006-4971 ] ; 2012.

RBID : Pascal:12-0398695

Descripteurs français

Pascal (Inist)
- Lymphome folliculaire, Pronostic, Homme, Polymorphisme, Variabilité génétique, Génotype, Hématologie, Gène FCGR3A, Gène FCGR2A, Hémopathie maligne lymphoïde, Hémopathie lymphoïde B.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- B cell neoplasm, Follicular lymphoma, Genetic variability, Genotype, Hematology, Human, Lymphoid neoplasm, Polymorphism, Prognosis.

Abstract

In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms</title>
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<author><name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>CHU de Nancy</s1>
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<country>France</country>
<placeName><region type="region">Grand Est</region>
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<author><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris</s1>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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</author>
<author><name sortKey="Bouabdallah, Reda" sort="Bouabdallah, Reda" uniqKey="Bouabdallah R" first="Réda" last="Bouabdallah">Réda Bouabdallah</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institut Paoli Calmettes</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
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<settlement type="city">Marseille</settlement>
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</author>
<author><name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>UCL, MT-Godinne</s1>
<s2>Yvoir</s2>
<s3>BEL</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<wicri:noRegion>Yvoir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dupuis, Jehan" sort="Dupuis, Jehan" uniqKey="Dupuis J" first="Jehan" last="Dupuis">Jehan Dupuis</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>CHU Henri Mondor</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>CHU de Dijon</s1>
<s2>Dijon</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Bourgogne</region>
<settlement type="city">Dijon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catalano, John Vincent" sort="Catalano, John Vincent" uniqKey="Catalano J" first="John Vincent" last="Catalano">John Vincent Catalano</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Frankston Hospital</s1>
<s2>Frankston</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Frankston Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Delmer, Alain" sort="Delmer, Alain" uniqKey="Delmer A" first="Alain" last="Delmer">Alain Delmer</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>CHU de Reims</s1>
<s2>Reims</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Champagne-Ardenne</region>
<settlement type="city">Reims</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jardin, Fabrice" sort="Jardin, Fabrice" uniqKey="Jardin F" first="Fabrice" last="Jardin">Fabrice Jardin</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Centre Henri Becquerel and UMR Inserm U918</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verney, Aurelie" sort="Verney, Aurelie" uniqKey="Verney A" first="Aurélie" last="Verney">Aurélie Verney</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dartigues, Peggy" sort="Dartigues, Peggy" uniqKey="Dartigues P" first="Peggy" last="Dartigues">Peggy Dartigues</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Claude Bernard, Unite Mixte de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 5239</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Hospices Civils de Lyon</s1>
<s2>Pierre-Benite</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pierre-Benite</wicri:noRegion>
<wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion>
<wicri:noRegion>Hospices Civils de Lyon</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>B cell neoplasm</term>
<term>Follicular lymphoma</term>
<term>Genetic variability</term>
<term>Genotype</term>
<term>Hematology</term>
<term>Human</term>
<term>Lymphoid neoplasm</term>
<term>Polymorphism</term>
<term>Prognosis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lymphome folliculaire</term>
<term>Pronostic</term>
<term>Homme</term>
<term>Polymorphisme</term>
<term>Variabilité génétique</term>
<term>Génotype</term>
<term>Hématologie</term>
<term>Gène FCGR3A</term>
<term>Gène FCGR2A</term>
<term>Hémopathie maligne lymphoïde</term>
<term>Hémopathie lymphoïde B</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bourgogne</li>
<li>Bourgogne-Franche-Comté</li>
<li>Champagne-Ardenne</li>
<li>Grand Est</li>
<li>Haute-Normandie</li>
<li>Languedoc-Roussillon</li>
<li>Lorraine (région)</li>
<li>Nouvelle-Aquitaine</li>
<li>Occitanie (région administrative)</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Province de Flandre-Orientale</li>
<li>Rhône-Alpes</li>
<li>Région Normandie</li>
<li>Région flamande</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bordeaux</li>
<li>Créteil</li>
<li>Dijon</li>
<li>Gand</li>
<li>Lyon</li>
<li>Marseille</li>
<li>Melbourne</li>
<li>Montpellier</li>
<li>Nancy</li>
<li>Paris</li>
<li>Reims</li>
<li>Rouen</li>
</settlement>
<orgName><li>Université de Gand</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquieres">Hervé Ghesquieres</name>
</region>
<name sortKey="Bouabdallah, Reda" sort="Bouabdallah, Reda" uniqKey="Bouabdallah R" first="Réda" last="Bouabdallah">Réda Bouabdallah</name>
<name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name>
<name sortKey="Cartron, Guillaume" sort="Cartron, Guillaume" uniqKey="Cartron G" first="Guillaume" last="Cartron">Guillaume Cartron</name>
<name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name>
<name sortKey="Dartigues, Peggy" sort="Dartigues, Peggy" uniqKey="Dartigues P" first="Peggy" last="Dartigues">Peggy Dartigues</name>
<name sortKey="Delfau Larue, Marie Helene" sort="Delfau Larue, Marie Helene" uniqKey="Delfau Larue M" first="Marie-Hélène" last="Delfau-Larue">Marie-Hélène Delfau-Larue</name>
<name sortKey="Delmer, Alain" sort="Delmer, Alain" uniqKey="Delmer A" first="Alain" last="Delmer">Alain Delmer</name>
<name sortKey="Dupuis, Jehan" sort="Dupuis, Jehan" uniqKey="Dupuis J" first="Jehan" last="Dupuis">Jehan Dupuis</name>
<name sortKey="Ghesquieres, Herve" sort="Ghesquieres, Herve" uniqKey="Ghesquieres H" first="Hervé" last="Ghesquieres">Hervé Ghesquieres</name>
<name sortKey="Jardin, Fabrice" sort="Jardin, Fabrice" uniqKey="Jardin F" first="Fabrice" last="Jardin">Fabrice Jardin</name>
<name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name>
<name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<name sortKey="Soubeyran, Pierre" sort="Soubeyran, Pierre" uniqKey="Soubeyran P" first="Pierre" last="Soubeyran">Pierre Soubeyran</name>
<name sortKey="Verney, Aurelie" sort="Verney, Aurelie" uniqKey="Verney A" first="Aurélie" last="Verney">Aurélie Verney</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name>
</region>
<name sortKey="Catalano, John Vincent" sort="Catalano, John Vincent" uniqKey="Catalano J" first="John Vincent" last="Catalano">John Vincent Catalano</name>
</country>
<country name="Belgique"><region name="Région flamande"><name sortKey="Offner, Fritz" sort="Offner, Fritz" uniqKey="Offner F" first="Fritz" last="Offner">Fritz Offner</name>
</region>
<name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name>
</country>
</tree>
</affiliations>
</record>

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Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms

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